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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1968 1
1969 1
1971 1
1972 1
1973 2
1974 2
1975 6
1976 2
1977 2
1978 1
1979 5
1980 5
1981 2
1982 3
1983 3
1984 4
1985 4
1986 4
1987 3
1988 4
1989 3
1990 2
1991 3
1992 3
1993 4
1994 4
1995 3
1996 7
1997 8
1998 7
1999 7
2000 8
2001 12
2002 21
2003 21
2004 18
2005 14
2006 11
2007 13
2008 20
2009 15
2010 17
2011 18
2012 19
2013 26
2014 14
2015 12
2016 17
2017 19
2018 17
2019 17
2020 17
2021 16
2022 6
2023 11
2024 5

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447 results

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Page 1
Hypertriglyceridemia-induced acute pancreatitis: progress on disease mechanisms and treatment modalities.
Guo YY, Li HX, Zhang Y, He WH. Guo YY, et al. Discov Med. 2019 Feb;27(147):101-109. Discov Med. 2019. PMID: 30939294 Free article. Review.
Acute pancreatitis (AP) is a common and destructive inflammatory condition of the pancreas. Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) has become the second major cause of AP. ...The mechanism responsible for HTG-AP is related to high-level free fatty acid ( …
Acute pancreatitis (AP) is a common and destructive inflammatory condition of the pancreas. Hypertriglyceridemia-induced acute pancre …
Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes.
Lytrivi M, Castell AL, Poitout V, Cnop M. Lytrivi M, et al. J Mol Biol. 2020 Mar 6;432(5):1514-1534. doi: 10.1016/j.jmb.2019.09.016. Epub 2019 Oct 16. J Mol Biol. 2020. PMID: 31628942 Free PMC article. Review.
The deleterious effects of chronically elevated free fatty acid (FFA) levels on glucose homeostasis are referred to as lipotoxicity, and the concurrent exposure to high glucose may cause synergistic glucolipotoxicity. ...Here, we review the current evidence supporting the …
The deleterious effects of chronically elevated free fatty acid (FFA) levels on glucose homeostasis are referred to as lipotoxicity, …
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven GM. Reaven GM. Diabetes. 1988 Dec;37(12):1595-607. doi: 10.2337/diab.37.12.1595. Diabetes. 1988. PMID: 3056758 Review.
The relationship between insulin resistance, plasma insulin level, and glucose intolerance is mediated to a significant degree by changes in ambient plasma free-fatty acid (FFA) concentration. Patients with NIDDM are also resistant to insulin suppression of plasma FFA …
The relationship between insulin resistance, plasma insulin level, and glucose intolerance is mediated to a significant degree by changes in …
Fat storage in pancreas and in insulin-sensitive tissues in pathogenesis of type 2 diabetes.
Assimacopoulos-Jeannet F. Assimacopoulos-Jeannet F. Int J Obes Relat Metab Disord. 2004 Dec;28 Suppl 4:S53-7. doi: 10.1038/sj.ijo.0802857. Int J Obes Relat Metab Disord. 2004. PMID: 15592487 Review.
In pancreatic beta cells, short-term excess of fatty acids or LC-CoA activates PKC and also directly stimulates insulin exocytosis. Long-term exposure to free fatty acids (FFA) leads to an increased basal and blunted glucose-stimulated insulin secretion by affecting gene e …
In pancreatic beta cells, short-term excess of fatty acids or LC-CoA activates PKC and also directly stimulates insulin exocytosis. Long-ter …
Maternal high fat diets: impacts on offspring obesity and epigenetic hypothalamic programming.
Harmancıoğlu B, Kabaran S. Harmancıoğlu B, et al. Front Genet. 2023 May 11;14:1158089. doi: 10.3389/fgene.2023.1158089. eCollection 2023. Front Genet. 2023. PMID: 37252665 Free PMC article. Review.
Maternal insulin resistance and inflammation lead to increased adipose tissue lipolysis, and also increased free fatty acid (FFA) intake during pregnancy (35% of energy from fat) cause a significant increase in FFA levels in the fetus. ...On the other hand, increase …
Maternal insulin resistance and inflammation lead to increased adipose tissue lipolysis, and also increased free fatty acid (FFA) int …
Potential roles of GPR120 and its agonists in the management of diabetes.
Zhang D, Leung PS. Zhang D, et al. Drug Des Devel Ther. 2014 Jul 29;8:1013-27. doi: 10.2147/DDDT.S53892. eCollection 2014. Drug Des Devel Ther. 2014. PMID: 25114508 Free PMC article. Review.
The main role of GPR120 is to elicit FFA regulation on metabolism homeostasis. GPR120 agonism correlates with prevention of the occurrence and development of metabolic disorders such as obesity and diabetes. ...This review summarizes recent advances in physiological roles …
The main role of GPR120 is to elicit FFA regulation on metabolism homeostasis. GPR120 agonism correlates with prevention of the occur …
[Hypertriglyceridemia-induced pancreatitis].
Nagayama D, Shirai K. Nagayama D, et al. Nihon Rinsho. 2013 Sep;71(9):1602-5. Nihon Rinsho. 2013. PMID: 24205721 Review. Japanese.
Havel has suggested that hydrolysis of excessive triglyceride-rich lipoproteins releases high concentrations of free fatty acid(FFA). The FFA micelles injure the vascular endothelium and acinar cells of the pancreas, producing a self-perpetuating ischemic and …
Havel has suggested that hydrolysis of excessive triglyceride-rich lipoproteins releases high concentrations of free fatty acid(FFA). …
Pancreatic and mucosal enzymes in choline phospholipid digestion.
Nilsson Å, Duan RD. Nilsson Å, et al. Am J Physiol Gastrointest Liver Physiol. 2019 Apr 1;316(4):G425-G445. doi: 10.1152/ajpgi.00320.2018. Epub 2018 Dec 21. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 30576217 Free article. Review.
In the proximal small intestine, hydrolysis of phosphatidylcholine (PC) to 1-lyso-PC and free fatty acid (FFA) by the pancreatic phospholipase A(2) IB coincides with the digestion of the dietary triacylglycerols by lipases, but part of the PC digestion is extended and must …
In the proximal small intestine, hydrolysis of phosphatidylcholine (PC) to 1-lyso-PC and free fatty acid (FFA) by the pancreatic phos …
Gut Microbiota: FFAR Reaching Effects on Islets.
Priyadarshini M, Navarro G, Layden BT. Priyadarshini M, et al. Endocrinology. 2018 Jun 1;159(6):2495-2505. doi: 10.1210/en.2018-00296. Endocrinology. 2018. PMID: 29846565 Free PMC article. Review.
The G protein-coupled receptors, free fatty acid (FFA) receptors 2 and 3 (FFA2 and FFA3), belonging to the free fatty acid receptor (FFAR) class, sense a distinct class of nutrients, short chain fatty acids (SCFAs). ...
The G protein-coupled receptors, free fatty acid (FFA) receptors 2 and 3 (FFA2 and FFA3), belonging to the free fatty acid receptor ( …
Neddylation-mediated degradation of hnRNPA2B1 contributes to hypertriglyceridemia pancreatitis.
Chen W, Wang Y, Xia W, Zhang J, Zhao Y. Chen W, et al. Cell Death Dis. 2022 Oct 11;13(10):863. doi: 10.1038/s41419-022-05310-w. Cell Death Dis. 2022. PMID: 36220838 Free PMC article.
Hypertriglyceridemia-induced acute pancreatitis (HTGP) is characterized by the acute and excessive release of FFA produced by pancreatic lipases. However, the underlying mechanisms of this disease remain poorly understood. ...Administration of MLN4924 in vivo restored hnRN …
Hypertriglyceridemia-induced acute pancreatitis (HTGP) is characterized by the acute and excessive release of FFA produced by pancrea …
447 results